Studies on the Mechanism of Interferon Action

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Studies on the Mechanism of Interferon Action

Interferon does not inactivate viruses or viral RNA. Virus growth is inhibited in interferon-treated cells, but apart from conferring resistance to virus growth, no other effect of interferon on cells has been definitely shown to take place. Interferon binds to cells even in the cold, but a period of incubation at 37 degrees C is required for development of antiviral activity. Cytoplasmic uptak...

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Studies on the Antiproliferative Action of Interferon

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Mechanism of Interferon Action

The double-stranded RNA (dsRNA)-dependent protein kinase which catalyzes the phosphorylation of ribosome-associated protein Pl and the a subunit of eukaryotic protein synthesis initiation factor 2 (eIF-2) was purified and characterized from mouse fibroblast L929 cells treated with either natural or recombinant interferon and from untreated cells. The dsRNA-dependent Pl/eIF-2a kinase was purifie...

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ژورنال

عنوان ژورنال: Journal of General Physiology

سال: 1970

ISSN: 1540-7748,0022-1295

DOI: 10.1085/jgp.56.1.149